A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist

Psychopharmacology (Berl). 2005 Aug;180(4):789-91. doi: 10.1007/s00213-005-0060-1. Epub 2005 Sep 14.
No abstract available

Publication types

  • Clinical Trial
  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Brain / drug effects*
  • Brain / metabolism
  • Carbon Isotopes / pharmacokinetics
  • Drug Interactions
  • Flumazenil / pharmacokinetics*
  • GABA Modulators / pharmacokinetics*
  • Humans
  • Isoindoles
  • Lorazepam / pharmacology
  • Male
  • Naphthyridines / pharmacology*
  • Positron-Emission Tomography / methods

Substances

  • Carbon Isotopes
  • GABA Modulators
  • Isoindoles
  • Naphthyridines
  • pagoclone
  • Flumazenil
  • Lorazepam