Abstract
Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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A Kinase Anchor Proteins
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Cell Cycle Proteins
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Cyclic AMP / metabolism
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Macromolecular Substances*
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Protein Binding
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Protein Isoforms / metabolism
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Proteins / metabolism
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Receptors, Adrenergic, beta-2 / metabolism
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Second Messenger Systems / physiology*
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Time Factors
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rho GTP-Binding Proteins / metabolism
Substances
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A Kinase Anchor Proteins
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AKAP12 protein, human
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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Macromolecular Substances
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Protein Isoforms
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Proteins
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Receptors, Adrenergic, beta-2
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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rho GTP-Binding Proteins