Abstract
In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.
MeSH terms
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Animals
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Antitussive Agents / pharmacology*
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Bronchoconstriction / drug effects*
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Bronchodilator Agents / pharmacology*
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Citrates
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Citric Acid
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Cough / chemically induced
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Cough / physiopathology*
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Female
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Guinea Pigs
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Ipratropium / pharmacology
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Lidocaine / pharmacology
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Male
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Terbutaline / pharmacology
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Theophylline / pharmacology
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Xanthines / pharmacology
Substances
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Antitussive Agents
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Bronchodilator Agents
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Citrates
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Xanthines
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Citric Acid
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Lidocaine
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Theophylline
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enprofylline
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Ipratropium
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Terbutaline