Therapeutic potential of vitamin D-binding protein

Trends Biotechnol. 2004 Jul;22(7):340-5. doi: 10.1016/j.tibtech.2004.05.001.

Abstract

Vitamin D-binding protein (DBP) is a multi-functional plasma protein with many important functions. These include transport of vitamin D metabolites, control of bone development, binding of fatty acids, sequestration of actin and a range of less-defined roles in modulating immune and inflammatory responses. Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Clinical Trials as Topic
  • Humans
  • Immunologic Factors / therapeutic use
  • Inflammation / drug therapy*
  • Macrophage Activation / drug effects
  • Macrophage Activation / immunology
  • Macrophages / metabolism
  • Neoplasms / drug therapy*
  • Osteopetrosis / drug therapy*
  • Protein Binding
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Vitamin D-Binding Protein / chemistry
  • Vitamin D-Binding Protein / immunology
  • Vitamin D-Binding Protein / metabolism*
  • Vitamin D-Binding Protein / therapeutic use*

Substances

  • Actins
  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Immunologic Factors
  • Vitamin D-Binding Protein