Abstract
Vitamin D-binding protein (DBP) is a multi-functional plasma protein with many important functions. These include transport of vitamin D metabolites, control of bone development, binding of fatty acids, sequestration of actin and a range of less-defined roles in modulating immune and inflammatory responses. Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases.
MeSH terms
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Actins / metabolism
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Animals
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Anti-Inflammatory Agents / therapeutic use
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Antineoplastic Agents / therapeutic use
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Clinical Trials as Topic
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Humans
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Immunologic Factors / therapeutic use
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Inflammation / drug therapy*
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Macrophage Activation / drug effects
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Macrophage Activation / immunology
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Macrophages / metabolism
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Neoplasms / drug therapy*
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Osteopetrosis / drug therapy*
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Protein Binding
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Pulmonary Disease, Chronic Obstructive / drug therapy*
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Vitamin D-Binding Protein / chemistry
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Vitamin D-Binding Protein / immunology
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Vitamin D-Binding Protein / metabolism*
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Vitamin D-Binding Protein / therapeutic use*
Substances
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Actins
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Immunologic Factors
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Vitamin D-Binding Protein