[Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride]

A Zh Abil'daeva; R N Pak; A T Kulyiasov; S M Adekenov

[Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride]

Eksp Klin Farmakol. 2004 Jan-Feb;67(1):37-9.

[Article in Russian]

Authors

A Zh Abil'daeva¹, R N Pak, A T Kulyiasov, S M Adekenov

Affiliation

¹ Laboratory of Phytopreparation Technology and Pharmacology, Institute of Phytochemistry, ul. Gazalieva 4, Karaganda, 470032 Kazakhstan.

PMID: 15079907

Abstract

The sesquiterpene lactone arglabin, as well as its derivative 11,13-Dihydro-13-dimethylaminoarglabin hydrochloride, exhibit antiexudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma.

MeSH terms

Acute Disease
Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Antineoplastic Agents / therapeutic use
Inflammation / drug therapy
Inflammation / etiology
Lactones / therapeutic use*
Male
Rats
Sesquiterpenes / therapeutic use*
Sesquiterpenes, Guaiane

Substances

11,13-dihydro-13-dimethylaminoarglabin hydrochloride
Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Lactones
Sesquiterpenes
Sesquiterpenes, Guaiane
arglabin