Abstract
Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs. Pokeweed antiviral protein is among the RIPs that have been conjugated to selective monoclonal antibodies for the treatment of several human cancers and viral diseases. Clinical trials using PAP immunotoxins for the treatment of leukemia have been particularly encouraging.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Antineoplastic Agents, Phytogenic / adverse effects
-
Antineoplastic Agents, Phytogenic / therapeutic use*
-
Antiviral Agents / adverse effects
-
Antiviral Agents / therapeutic use*
-
HIV / drug effects*
-
Humans
-
Leukemia / drug therapy*
-
Molecular Sequence Data
-
N-Glycosyl Hydrolases*
-
Plant Proteins / adverse effects
-
Plant Proteins / therapeutic use*
-
RNA, Ribosomal, 28S / drug effects*
-
Ribosome Inactivating Proteins, Type 1
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents, Phytogenic
-
Antiviral Agents
-
Plant Proteins
-
RNA, Ribosomal, 28S
-
Ribosome Inactivating Proteins, Type 1
-
N-Glycosyl Hydrolases
-
pokeweed antiviral protein