Dopamine transporter imaging with novel, selective cocaine analogs

Neuroreport. 1992 Nov;3(11):969-72. doi: 10.1097/00001756-199211000-00005.

Abstract

RTI-121 and RTI-122 are 3 beta-substituted phenyltropane analogs of cocaine that have high, selective binding affinity for dopamine transporters. [123I]RTI-121 and [123I]RTI-122 bind to dopamine transporters in vivo after intravenous administration and permit imaging of the transporters.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / anatomy & histology
  • Brain Chemistry
  • Carrier Proteins / analysis
  • Carrier Proteins / metabolism*
  • Cocaine / analogs & derivatives*
  • Dopamine Plasma Membrane Transport Proteins
  • Iodine Radioisotopes
  • Kinetics
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Mice
  • Nerve Tissue Proteins*
  • Papio
  • Protein Binding
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Iodine Radioisotopes
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • RTI 121
  • 3-(4-iodophenyl)tropan-2beta-carboxylic acid phenyl ester
  • Cocaine