A case of rifampicin induced pseudomembraneous colitis

Saudi Med J. 2003 Dec;24(12):1391-3.

Abstract

We report a case pf pseudomembranous colitis that developed in a patient with tuberculous abdominal lymphadenopathy during treatment with rifampicin. The patient had delayed presentation (3 months) after the start of rifampicin. She had one relapse after 2 months that was successfully treated, and she finished her antituberculosis therapy without any further relapses. Awareness of this serious complication of rifampicin therapy should be encountered.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / diagnosis
  • Abdominal Pain / etiology
  • Adult
  • Biopsy, Needle
  • Colonoscopy / methods
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Enterocolitis, Pseudomembranous / chemically induced*
  • Enterocolitis, Pseudomembranous / drug therapy
  • Enterocolitis, Pseudomembranous / pathology*
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Metronidazole / therapeutic use
  • Rifampin / adverse effects*
  • Rifampin / therapeutic use
  • Treatment Outcome
  • Tuberculosis, Lymph Node / diagnosis
  • Tuberculosis, Lymph Node / drug therapy

Substances

  • Metronidazole
  • Rifampin