Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue

J Med Chem. 1992 Dec 11;35(25):4764-6. doi: 10.1021/jm00103a015.

Authors

A P Kozikowski¹, M Roberti, L Xiang, J S Bergmann, P M Callahan, K A Cunningham, K M Johnson

Affiliation

¹ Neurochemistry Research, Mayo Foundation for Education and Research, Jacksonville, Florida 32224.

PMID: 1469704
DOI: 10.1021/jm00103a015

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Binding, Competitive
Brain / drug effects
Brain / metabolism
Cocaine / analogs & derivatives*
Discrimination Learning
Mazindol / metabolism
Rats
Structure-Activity Relationship

Substances

Mazindol
Cocaine