Peroxidative stress effects on calpain activity in brain of young and adult rats

M Benuck; M Banay-Schwartz; M T Ramacci; A Lajtha

doi:10.1016/0006-8993(92)91560-2

Peroxidative stress effects on calpain activity in brain of young and adult rats

Brain Res. 1992 Nov 20;596(1-2):296-8. doi: 10.1016/0006-8993(92)91560-2.

Authors

M Benuck¹, M Banay-Schwartz, M T Ramacci, A Lajtha

Affiliation

¹ N.S. Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962.

PMID: 1467990
DOI: 10.1016/0006-8993(92)91560-2

Abstract

Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, counteracting the effect of the pro-oxidant.

MeSH terms

Aging / metabolism*
Animals
Brain / metabolism*
Calpain / metabolism*
Carnitine / analogs & derivatives
Carnitine / pharmacology
Cathepsin D / metabolism
Cyclohexanones*
Rats
Rats, Sprague-Dawley
Stress, Physiological / chemically induced
Stress, Physiological / metabolism*

Substances

Cyclohexanones
3-methylbutyrylcarnitine
2-cyclohexen-1-one
Calpain
Cathepsin D
Carnitine