Control of transcription factors by signal transduction pathways: the beginning of the end

M Karin; T Smeal

doi:10.1016/0968-0004(92)90012-x

Control of transcription factors by signal transduction pathways: the beginning of the end

Trends Biochem Sci. 1992 Oct;17(10):418-22. doi: 10.1016/0968-0004(92)90012-x.

Authors

M Karin¹, T Smeal

Affiliation

¹ Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla 92093-0636.

PMID: 1455510
DOI: 10.1016/0968-0004(92)90012-x

Abstract

Signal transduction pathways regulate gene expression by modulating the activity of nuclear transcription factors. The mechanisms that control the activity of two groups of sequence-specific transcription factors, the AP-1 and CREB/ATF proteins, are described. These factors serve as a paradigm explaining the transfer of regulatory information from the cell surface to the nucleus.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Activating Transcription Factors
Animals
Blood Proteins / physiology*
Gene Expression Regulation / physiology
Humans
Phosphorylation
Proto-Oncogene Proteins c-jun / physiology*
Signal Transduction / physiology*
Transcription Factors / physiology*

Substances

Activating Transcription Factors
Blood Proteins
Proto-Oncogene Proteins c-jun
Transcription Factors