Abstract
1. A variety of prostanoids were examined for their ability to alter the periarterial nerve stimulation-induced release of noradrenaline (NA) and neuropeptide Y immunoreactive compounds (NPY-ir) from the perfused mesenteric arterial bed of the rat. 2. Periarterial nerve stimulation (16 Hz) increased the overflow of NA, NPY-ir and perfusion pressure. 3. The prostacyclin (PGI2) analogues, carbaPGI2 and cicaprost both produced a concentration-dependent attenuation of the nerve stimulation-induced increase in NA, NPY-ir overflow and perfusion pressure. 4. The prostaglandin (PG) analogue PGE2 attenuated the evoked increase in NPY-ir overflow as well as a modest decrease in NA. 5. PGE1, sulprostone and iloprost attenuated the nerve stimulation-induced increase in NA overflow but not NPY-ir. 6. Neither PGF2alpha nor the thromboxane A2 analogue U46619 altered the evoked increase in NA or NPY-ir overflow. 7. The results support the view that sympathetic co-transmitter release can be differentially modulated by paracrine/autocrine mediators at sympathetic neuroeffector junctions.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / administration & dosage
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Alprostadil / pharmacology
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Animals
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Dinoprost / administration & dosage
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Dinoprost / analogs & derivatives
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Dinoprostone / analogs & derivatives*
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Dinoprostone / pharmacology
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Electric Stimulation / methods
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Epoprostenol / analogs & derivatives*
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Epoprostenol / pharmacology
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Iloprost / pharmacology
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Male
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Mesenteric Arteries / drug effects
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Mesenteric Arteries / innervation
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Mesenteric Arteries / metabolism*
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Neuropeptide Y / antagonists & inhibitors
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Neuropeptide Y / chemistry
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Neuropeptide Y / metabolism*
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Norepinephrine / antagonists & inhibitors
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Norepinephrine / chemistry
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Norepinephrine / metabolism*
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Perfusion / methods
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Prostaglandins / pharmacology*
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Radioimmunoassay / methods
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Rats
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Rats, Sprague-Dawley
Substances
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Neuropeptide Y
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Prostaglandins
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8-epi-prostaglandin F2alpha
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sulprostone
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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Dinoprost
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Epoprostenol
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Alprostadil
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Iloprost
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Dinoprostone
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cicaprost
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Norepinephrine