Abstract
The polycystic kidney diseases (PKDs) are a group of genetic disorders causing significant renal failure and death in children and adults. There are no effective treatments. Two childhood forms, autosomal recessive PKD (ARPKD) and nephronophthisis (NPH), are characterized by collecting-duct cysts. We used animal models orthologous to the human disorders to test whether a vasopressin V2 receptor (VPV2R) antagonist, OPC31260, would be effective against early or established disease. Adenosine-3',5'-cyclic monophosphate (cAMP) has a major role in cystogenesis, and the VPV2R is the major cAMP agonist in the collecting duct. OPC31260 administration lowered renal cAMP, inhibited disease development and either halted progression or caused regression of established disease. These results indicate that OPC31260 may be an effective treatment for these disorders and that clinical trials should be considered.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antidiuretic Hormone Receptor Antagonists*
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Aquaporin 2
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Aquaporin 6
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Aquaporins / genetics
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Aquaporins / metabolism
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Benzazepines / metabolism
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Benzazepines / therapeutic use*
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Cyclic AMP / metabolism
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Disease Models, Animal
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Disease Progression
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Humans
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Kidney / metabolism
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Kidney / pathology
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Mice
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Polycystic Kidney Diseases / drug therapy*
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Polycystic Kidney Diseases / metabolism*
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Polycystic Kidney Diseases / physiopathology
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Proteins / genetics
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Proteins / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Vasopressin / metabolism*
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TRPP Cation Channels
Substances
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AQP2 protein, human
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Antidiuretic Hormone Receptor Antagonists
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Aqp2 protein, mouse
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Aqp2 protein, rat
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Aquaporin 2
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Aquaporin 6
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Aquaporins
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Benzazepines
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Proteins
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Receptors, Vasopressin
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TRPP Cation Channels
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polycystic kidney disease 1 protein
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mozavaptan
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Cyclic AMP