Abstract
Automutilation induced by a single large dose of clonidine was potentiated by pretreatment with methamphetamine, caffeine and theophyline, while it was inhibited by acute administration of reserpine, alpha-methyl-p-tyrosine, phenoxybenzamine, phentolamine and chlorpromazine. L-Dopa, 5-hydroxytryptophan and p-chlorophenylalanine had no effect on this abnormal behavior. Biochemical studies on brain monoamines revealed that noradrenaline was markedly increased and dopamine slightly so, but 5-hydroxytryptamine was never changed by clonidine. These results suggest that a central noradrenergic system may be involved in automutilation induced by clonidine in mice.
MeSH terms
-
5-Hydroxytryptophan / pharmacology
-
Animals
-
Brain / drug effects*
-
Brain Chemistry
-
Caffeine / pharmacology
-
Catecholamines / analysis
-
Chlorpromazine / pharmacology
-
Clonidine* / administration & dosage
-
Clonidine* / antagonists & inhibitors
-
Clonidine* / pharmacology
-
Dose-Response Relationship, Drug
-
Drug Synergism
-
Fenclonine / pharmacology
-
Humans
-
Levodopa / pharmacology
-
Male
-
Methamphetamine / pharmacology
-
Methyltyrosines / pharmacology
-
Mice
-
Phenoxybenzamine / pharmacology
-
Phentolamine / pharmacology
-
Reserpine / pharmacology
-
Self Mutilation / chemically induced*
-
Sympathetic Nervous System / drug effects*
-
Theophylline / pharmacology
Substances
-
Catecholamines
-
Methyltyrosines
-
Phenoxybenzamine
-
Caffeine
-
Methamphetamine
-
Levodopa
-
Reserpine
-
Theophylline
-
5-Hydroxytryptophan
-
Clonidine
-
Fenclonine
-
Chlorpromazine
-
Phentolamine