Abstract
Sertraline, a potent and selective serotonin uptake inhibitor, was used to analyze the changes occurring in the serotonin system after uptake inhibition in vivo. Sertraline (11 mg/kg) lowered extracellular 5-hydroxyindolacetic acid (5-HIAA), measured in rat hippocampus by in vivo voltammetry, for about 3 h. The interaction between sertraline and drugs known to interfere with the release or uptake of serotonin (L-5-hydroxytryptophan (5-HTP), d-norfenfluramine and tianeptine) was then studied. The sertraline-induced decrease in extracellular 5-HIAA was related to the inhibition of uptake.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Naphthylamine / analogs & derivatives*
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1-Naphthylamine / pharmacology
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5-Hydroxytryptophan / pharmacology
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Animals
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Antidepressive Agents, Tricyclic / pharmacology
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Dopamine / metabolism
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Electrodes, Implanted
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Hydroxyindoleacetic Acid / metabolism
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Male
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Norepinephrine / metabolism
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Norfenfluramine / pharmacology
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism*
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Sertraline
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Thiazepines / pharmacology
Substances
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Antidepressive Agents, Tricyclic
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Thiazepines
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tianeptine
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Norfenfluramine
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Serotonin
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Hydroxyindoleacetic Acid
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1-Naphthylamine
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5-Hydroxytryptophan
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Sertraline
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Dopamine
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Norepinephrine