Abstract
Intra- and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine-sensitive neurones were encountered which were potently excited by bath application of the NK3 receptor agonist, senktide. On these senktide-sensitive neurones, NK1 and NK2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.
MeSH terms
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Animals
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Dopamine / physiology*
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In Vitro Techniques
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Male
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Neurons / drug effects*
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Peptide Fragments / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, Neurotransmitter / drug effects*
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Receptors, Tachykinin
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Substance P / analogs & derivatives*
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Substance P / pharmacology
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Substance P / physiology*
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Substantia Nigra / cytology
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Substantia Nigra / drug effects*
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Tachykinins
Substances
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Peptide Fragments
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Receptors, Neurotransmitter
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Receptors, Tachykinin
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Tachykinins
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senktide
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Substance P
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Dopamine