Abstract
We investigated the effect of ifenprodil on excitotoxic cell death induced by acute exposure to glutamate receptor agonists in primary cultures of foetal mouse cerebral cortex. L-Glutamate and N-methyl-D-aspartate (NMDA) but not kainate and quisqualate-induced toxicity was attenuated in the presence of ifenprodil. In addition, ifenprodil and MK-801 blocked NaCN-induced toxicity. It is concluded that the cerebro-protective properties of ifenprodil in these models are mediated by NMDA receptor antagonism.
MeSH terms
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Animals
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Cell Death / drug effects
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Cells, Cultured
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Cerebral Cortex / drug effects
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Cyanates / toxicity
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Dizocilpine Maleate / pharmacology
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Glutamates / toxicity
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Glutamic Acid
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Kainic Acid / toxicity
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Mice
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N-Methylaspartate / toxicity
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Neurons / drug effects*
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Piperidines / pharmacology*
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Quisqualic Acid / pharmacology
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Substances
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Cyanates
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Glutamates
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Piperidines
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Receptors, N-Methyl-D-Aspartate
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Glutamic Acid
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N-Methylaspartate
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Dizocilpine Maleate
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Quisqualic Acid
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sodium cyanate
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ifenprodil
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Kainic Acid