Abstract
Two potent glutamate antagonists, NBQX and GYKI 52466, that act selectively on non-NMDA receptors, have been tested for anticonvulsant activity in 3 models of reflex epilepsy (sound-induced seizures in DBA/2 mice and in genetically epilepsy-prone rats and photically-induced myoclonus in Papio papio) and in amygdala kindled rats. Both compounds potently but transiently suppress reflexly-induced epileptic responses. GYKI 52466 also reduces behavioral seizures and afterdischarge duration in amygdala kindled rats, but with a lower potency than it suppresses reflex epilepsy. These data are similar to earlier results with antagonists acting selectively on NMDA receptors; they do not support a specific involvement of enhanced AMPA receptor sensitivity as a major factor in the expression of kindled seizures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acoustic Stimulation
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Amygdala / drug effects
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Amygdala / physiology
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Animals
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Anti-Anxiety Agents*
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Anticonvulsants / pharmacology*
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Benzodiazepines / pharmacology*
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Cerebral Cortex / drug effects
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Cerebral Cortex / physiology
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Electroencephalography / drug effects
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Epilepsies, Myoclonic / physiopathology
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Epilepsy / physiopathology*
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Evoked Potentials / drug effects
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Evoked Potentials / physiology
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Excitatory Amino Acid Antagonists*
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Hippocampus / drug effects
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Hippocampus / physiopathology
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Kindling, Neurologic / drug effects*
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Kindling, Neurologic / physiology
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Mice
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Mice, Inbred DBA
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Neural Pathways / drug effects
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Neural Pathways / physiology
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Papio
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Photic Stimulation
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Quinoxalines / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, AMPA
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Receptors, Glutamate / physiology
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Reflex / drug effects*
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Reflex / physiology
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Synaptic Transmission / drug effects*
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Synaptic Transmission / physiology
Substances
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Anti-Anxiety Agents
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Anticonvulsants
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Excitatory Amino Acid Antagonists
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Quinoxalines
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Receptors, AMPA
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Receptors, Glutamate
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GYKI 52466
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2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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Benzodiazepines