Abstract
Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ciguatoxins / chemical synthesis*
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Ciguatoxins / toxicity*
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Dinoflagellida / chemistry*
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Ethers, Cyclic / chemical synthesis*
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Ethers, Cyclic / toxicity*
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Indicators and Reagents
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Lethal Dose 50
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Mice
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / toxicity*
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Structure-Activity Relationship
Substances
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Ethers, Cyclic
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Indicators and Reagents
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Polycyclic Compounds
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gambierol
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Ciguatoxins