Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A

Thomas A Munro; Mark A Rizzacasa

doi:10.1021/np0205699

Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A

J Nat Prod. 2003 May;66(5):703-5. doi: 10.1021/np0205699.

Authors

Thomas A Munro¹, Mark A Rizzacasa

Affiliation

¹ School of Chemistry, The University of Melbourne, Victoria, 3010, Australia.

PMID: 12762813
DOI: 10.1021/np0205699

Abstract

Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Animals
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Diterpenes, Clerodane
Feeding Behavior / drug effects
Mexico
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Salvia / chemistry*
Spodoptera / drug effects
Tenebrio / drug effects

Substances

Diterpenes
Diterpenes, Clerodane
salvinorin D
salvinorin E
salvinorin F