Novel strategies for the treatment of sepsis

Nat Med. 2003 May;9(5):517-24. doi: 10.1038/nm0503-517.

Abstract

The history of therapeutic interventions in clinical trials for sepsis has been referred to as the "graveyard for pharmaceutical companies." That is now set to change, as research provides hope for new approaches that will be therapeutically effective in humans with sepsis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Apoptosis
  • Complement C5a / antagonists & inhibitors
  • HMGB1 Protein / physiology
  • Humans
  • Macrophage Migration-Inhibitory Factors / physiology
  • Protein C / therapeutic use
  • Receptor, Anaphylatoxin C5a
  • Receptors, Complement / antagonists & inhibitors
  • Sepsis / drug therapy*
  • Sepsis / etiology

Substances

  • Antigens, CD
  • HMGB1 Protein
  • Macrophage Migration-Inhibitory Factors
  • Protein C
  • Receptor, Anaphylatoxin C5a
  • Receptors, Complement
  • Complement C5a