Abstract
Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Chromatography, Thin Layer
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Colony-Forming Units Assay
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Coloring Agents
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Melanoma / drug therapy*
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Melanoma / pathology
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Neutral Red
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Nitrosourea Compounds / chemical synthesis*
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Nitrosourea Compounds / pharmacology*
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O(6)-Methylguanine-DNA Methyltransferase / metabolism
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Coloring Agents
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Indicators and Reagents
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Nitrosourea Compounds
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Organophosphorus Compounds
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Neutral Red
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O(6)-Methylguanine-DNA Methyltransferase
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fotemustine