Abstract
COX-2 inhibitors are a new class of nonsteroidal anti-inflammatory drugs with a reported benefit of less gastric and duodenal ulceration and hemorrhage. We describe a 67-year-old man taking a higher than usual dose of celecoxib (Celebrex) for osteoarthritis with resultant gastric erosions, ulceration, and a significant gastrointestinal (GI) hemorrhage.
MeSH terms
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Celecoxib
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Cyclooxygenase Inhibitors / administration & dosage
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Cyclooxygenase Inhibitors / adverse effects*
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Duodenal Ulcer / chemically induced*
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Gastrointestinal Hemorrhage / chemically induced*
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Humans
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Male
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Osteoarthritis / drug therapy
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Pyrazoles
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Sulfonamides / administration & dosage
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Sulfonamides / adverse effects*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Pyrazoles
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Sulfonamides
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Celecoxib