Tor signalling in bugs, brain and brawn

Estela Jacinto; Michael N Hall

doi:10.1038/nrm1018

Tor signalling in bugs, brain and brawn

Nat Rev Mol Cell Biol. 2003 Feb;4(2):117-26. doi: 10.1038/nrm1018.

Authors

Estela Jacinto¹, Michael N Hall

Affiliation

¹ Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

PMID: 12563289
DOI: 10.1038/nrm1018

Abstract

TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drosophila Proteins / physiology*
Drosophila melanogaster
Humans
Phosphatidylinositol 3-Kinases / physiology*
Phosphotransferases (Alcohol Group Acceptor) / physiology*
Receptor Protein-Tyrosine Kinases / physiology*
Saccharomyces cerevisiae Proteins / physiology*
Signal Transduction*
Tacrolimus Binding Protein 1A / physiology*

Substances

Drosophila Proteins
Saccharomyces cerevisiae Proteins
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
TOR1 protein, S cerevisiae
Receptor Protein-Tyrosine Kinases
tor protein, Drosophila
Tacrolimus Binding Protein 1A