Abstract
The importance of dopamine D3 receptors in reward related processes, especially in cocaine addiction, has been investigated extensively. However, in the reported studies a combination of different experimental conditions and different ligands have been used which renders the interpretation and comparison of the diverse results extremely difficult. Here, we report one comparative study investigating a wide range of dopamine D3 receptor ligands in one model of cocaine abuse: the place conditioning paradigm in rats. Of the antagonists tested, the moderately D3 selective nafadotride and the more selective SB-277011 did not produce any place conditioning effect while U-99194A caused place-preference. The most D3 selective agonist PD-128907, the less selective 7-OH-DPAT and the moderately selective partial agonist BP-897 all caused significant place aversion. None of the compounds influenced the cocaine-induced place preference. Results suggest the D3-preferring agonists could affect the reward mechanisms of the brain, however, modulation of D3 receptor function does not appear to be a significant mechanism for modifying the place conditioning effect of cocaine.
Copyright 2003 Lippincott Williams & Wilkins
MeSH terms
-
Animals
-
Avoidance Learning / drug effects*
-
Benzazepines / pharmacology
-
Benzopyrans / pharmacology
-
Cocaine / pharmacology
-
Cocaine / toxicity*
-
Conditioning, Classical / drug effects*
-
Dopamine Agonists / pharmacology*
-
Dopamine Antagonists / pharmacology*
-
Dopamine D2 Receptor Antagonists
-
Haloperidol / pharmacology
-
Indans / pharmacology
-
Male
-
Naphthalenes / pharmacology
-
Nitriles / pharmacology
-
Oxazines / pharmacology
-
Piperazines / pharmacology
-
Pyrrolidines / pharmacology
-
Quinolines / pharmacology
-
Rats
-
Rats, Sprague-Dawley
-
Receptors, Dopamine D1 / antagonists & inhibitors
-
Receptors, Dopamine D2 / drug effects
-
Receptors, Dopamine D2 / physiology*
-
Receptors, Dopamine D3
-
Reinforcement, Psychology
-
Reward*
-
Spatial Behavior / drug effects*
-
Substance-Related Disorders / physiopathology*
-
Tetrahydroisoquinolines*
-
Tetrahydronaphthalenes / pharmacology
Substances
-
Benzazepines
-
Benzopyrans
-
Dopamine Agonists
-
Dopamine Antagonists
-
Dopamine D2 Receptor Antagonists
-
Drd3 protein, rat
-
Indans
-
Naphthalenes
-
Nitriles
-
Oxazines
-
Piperazines
-
Pyrrolidines
-
Quinolines
-
Receptors, Dopamine D1
-
Receptors, Dopamine D2
-
Receptors, Dopamine D3
-
SB 277011
-
Tetrahydroisoquinolines
-
Tetrahydronaphthalenes
-
3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol
-
(5,6-dimethoxyindan-2-yl)dipropylamine
-
BP 897
-
Cocaine
-
Haloperidol
-
nafadotride
-
7-hydroxy-2-N,N-dipropylaminotetralin