Abstract
The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Chromatography, High Pressure Liquid
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Drug Resistance, Microbial
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Italy
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Mass Spectrometry
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Molecular Structure
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Myrtaceae / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Phloroglucinol / analogs & derivatives
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Phloroglucinol / chemistry
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Phloroglucinol / isolation & purification*
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Phloroglucinol / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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myrtucommulone A
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semimyrtucommulone
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Phloroglucinol