Abstract
The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation.
Copyright 2001 Wiley-Liss, Inc.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amyloid beta-Protein Precursor / genetics
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Amyloid beta-Protein Precursor / metabolism
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Animals
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Gene Expression Regulation / physiology*
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Genes, Regulator / physiology
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Humans
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Myelin Basic Protein / biosynthesis
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Myelin Basic Protein / genetics
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Nervous System / growth & development
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Nervous System / metabolism*
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Protein Biosynthesis / physiology*
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RNA Processing, Post-Transcriptional / physiology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
Substances
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Amyloid beta-Protein Precursor
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Myelin Basic Protein
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RNA, Messenger
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RNA-Binding Proteins