Abstract
The effect of tetramethylenedisulphotetramine (TETS) on the increase in membrane conductance produced by gamma-aminobutyric acid (GABA) at the hermit crab neuromuscular junction was investigated. TETS produced a dose-dependent antagonism of GABA, which was characterized by a non-parallel shift of the log dose-conductance curve for GABA with a reduced maximal conductance change.
MeSH terms
-
Aminobutyrates / pharmacology*
-
Animals
-
Anomura / physiology*
-
Bridged-Ring Compounds
-
Electric Conductivity / drug effects*
-
GABA Antagonists
-
In Vitro Techniques
-
Neuromuscular Junction / drug effects*
-
Polyamines / pharmacology*
-
Sulfones / pharmacology
-
Synaptic Membranes / drug effects*
-
gamma-Aminobutyric Acid / pharmacology*
Substances
-
Aminobutyrates
-
Bridged-Ring Compounds
-
GABA Antagonists
-
Polyamines
-
Sulfones
-
gamma-Aminobutyric Acid
-
tetramethylenedisulfotetramine