An elusive receptor is finally caught: P2Y(12'), an important drug target in platelets

E A Barnard; J Simon

doi:10.1016/s0165-6147(00)01759-4

An elusive receptor is finally caught: P2Y(12'), an important drug target in platelets

Trends Pharmacol Sci. 2001 Aug;22(8):388-91. doi: 10.1016/s0165-6147(00)01759-4.

Authors

E A Barnard¹, J Simon

Affiliation

¹ Dept of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK CB2 1QJ. eb247@cam.ac.uk

PMID: 11478981
DOI: 10.1016/s0165-6147(00)01759-4

Abstract

Despite intensive research, the nucleotide P2 receptor that is involved in the aggregation and activation of platelets by ADP has remained elusive. However, now two research groups have independently identified a new platelet receptor of unexpected structure, P2Y(12), that acts with the P2Y(1) receptor to form the site of ADP activation and explains the multiple transduction mechanisms observed in response to ADP in platelets. Recent evidence also suggests that a third component, ATP action on the P2X(1) receptor ion channel, contributes to platelet activation.

Publication types

Clinical Trial
Clinical Trial, Phase III
Review

MeSH terms

Adenosine Diphosphate / physiology
Adenosine Triphosphate / physiology
Animals
Blood Platelets / physiology*
Humans
Membrane Proteins*
Purinergic P2 Receptor Agonists
Purinergic P2 Receptor Antagonists
Receptors, Purinergic P2* / physiology
Receptors, Purinergic P2Y12
Research

Substances

Membrane Proteins
P2RY12 protein, human
Purinergic P2 Receptor Agonists
Purinergic P2 Receptor Antagonists
Receptors, Purinergic P2
Receptors, Purinergic P2Y12
Adenosine Diphosphate
Adenosine Triphosphate