The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?

J Clin Invest. 2001 Jul;108(2):181-3. doi: 10.1172/JCI13508.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Comment

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology
  • Collagenases / metabolism
  • Enzyme Inhibitors / therapeutic use*
  • Flavonoids / therapeutic use
  • Humans
  • Imidazoles / therapeutic use
  • Matrix Metalloproteinase 1 / metabolism
  • Matrix Metalloproteinase 13
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors*
  • Pyridines / therapeutic use
  • Signal Transduction / drug effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Enzyme Inhibitors
  • Flavonoids
  • Imidazoles
  • Pyridines
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinases
  • Collagenases
  • MMP13 protein, human
  • Matrix Metalloproteinase 13
  • Matrix Metalloproteinase 1
  • SB 203580
  • 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one