Abstract
EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility.
MeSH terms
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Alprostadil / analogs & derivatives*
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Alprostadil / chemical synthesis
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Animals
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Binding Sites / physiology
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CHO Cells / metabolism
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Cricetinae
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Cyclic AMP / agonists
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Cyclobutanes / chemical synthesis*
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Cyclobutanes / pharmacology*
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / pharmacology*
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Dinoprostone / metabolism
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Dinoprostone / pharmacology
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Drug Design
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Female
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Humans
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Ligands
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Mice
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Rats
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Receptors, Prostaglandin E / agonists*
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Receptors, Prostaglandin E, EP2 Subtype
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Sensitivity and Specificity
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Uterine Contraction / drug effects*
Substances
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Cyclobutanes
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Cyclopentanes
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Ligands
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PTGER2 protein, human
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Ptger2 protein, mouse
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP2 Subtype
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Cyclic AMP
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Alprostadil
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butaprost
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Dinoprostone