Is antigen presentation the primary function of HLA-G?

Microbes Infect. 2001 Apr;3(4):323-32. doi: 10.1016/s1286-4579(01)01386-7.

Abstract

Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Antigen Presentation*
  • Female
  • HLA Antigens / genetics
  • HLA Antigens / immunology
  • HLA Antigens / physiology*
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class I / physiology*
  • Humans
  • Immunity, Active
  • Immunity, Innate
  • Placenta / immunology
  • Pregnancy
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • T-Lymphocytes / immunology

Substances

  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I
  • Receptors, Antigen, T-Cell, alpha-beta