Abstract
Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Alleles
-
Antigen Presentation*
-
Female
-
HLA Antigens / genetics
-
HLA Antigens / immunology
-
HLA Antigens / physiology*
-
HLA-G Antigens
-
Histocompatibility Antigens Class I / genetics
-
Histocompatibility Antigens Class I / immunology
-
Histocompatibility Antigens Class I / physiology*
-
Humans
-
Immunity, Active
-
Immunity, Innate
-
Placenta / immunology
-
Pregnancy
-
Receptors, Antigen, T-Cell, alpha-beta / immunology
-
T-Lymphocytes / immunology
Substances
-
HLA Antigens
-
HLA-G Antigens
-
Histocompatibility Antigens Class I
-
Receptors, Antigen, T-Cell, alpha-beta