Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia

Pacing Clin Electrophysiol. 2001 Jan;24(1):119-21. doi: 10.1046/j.1460-9592.2001.00119.x.

Abstract

We report a 68-year-old man who developed torsades de pointes ventricular tachycardia induced by combined use of mosapride and flecainide. He had a permanent pacemaker (DDD mode) implanted because of sick sinus syndrome (bradytachy syndrome) 6 years earlier. The patient had started taking mosapride for upper abdominal discomfort 2 weeks earlier. On admission, ECG showed prolongation of the QTc interval from 0.48 to 0.56 seconds and self-terminating torsades de pointes occurred. We considered that this proarrhythmia was induced by mosapride in combination with antiarrhythmic agents.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Atrial Fibrillation / drug therapy
  • Benzamides / adverse effects*
  • Benzamides / therapeutic use
  • Drug Therapy, Combination
  • Electrocardiography
  • Flecainide / adverse effects*
  • Flecainide / therapeutic use
  • Gastrointestinal Agents / adverse effects*
  • Gastrointestinal Agents / therapeutic use
  • Humans
  • Hypokalemia / complications*
  • Male
  • Morpholines / adverse effects*
  • Morpholines / therapeutic use
  • Pacemaker, Artificial
  • Sick Sinus Syndrome / therapy
  • Torsades de Pointes / chemically induced*

Substances

  • Anti-Arrhythmia Agents
  • Benzamides
  • Gastrointestinal Agents
  • Morpholines
  • mosapride
  • Flecainide