Abstract
We report a 68-year-old man who developed torsades de pointes ventricular tachycardia induced by combined use of mosapride and flecainide. He had a permanent pacemaker (DDD mode) implanted because of sick sinus syndrome (bradytachy syndrome) 6 years earlier. The patient had started taking mosapride for upper abdominal discomfort 2 weeks earlier. On admission, ECG showed prolongation of the QTc interval from 0.48 to 0.56 seconds and self-terminating torsades de pointes occurred. We considered that this proarrhythmia was induced by mosapride in combination with antiarrhythmic agents.
MeSH terms
-
Aged
-
Anti-Arrhythmia Agents / adverse effects*
-
Anti-Arrhythmia Agents / therapeutic use
-
Atrial Fibrillation / drug therapy
-
Benzamides / adverse effects*
-
Benzamides / therapeutic use
-
Drug Therapy, Combination
-
Electrocardiography
-
Flecainide / adverse effects*
-
Flecainide / therapeutic use
-
Gastrointestinal Agents / adverse effects*
-
Gastrointestinal Agents / therapeutic use
-
Humans
-
Hypokalemia / complications*
-
Male
-
Morpholines / adverse effects*
-
Morpholines / therapeutic use
-
Pacemaker, Artificial
-
Sick Sinus Syndrome / therapy
-
Torsades de Pointes / chemically induced*
Substances
-
Anti-Arrhythmia Agents
-
Benzamides
-
Gastrointestinal Agents
-
Morpholines
-
mosapride
-
Flecainide