Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. doi: 10.1016/s0960-894x(00)00596-5.

Abstract

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemical synthesis
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Cycle / drug effects
  • Cell Division / drug effects
  • Colchicine / antagonists & inhibitors
  • Colchicine / metabolism
  • Ethers / chemical synthesis
  • Ethers / chemistry
  • Ethers / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plants, Medicinal / chemistry
  • Protein Binding / drug effects
  • Stilbenes / chemical synthesis
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*
  • Tubulin / metabolism
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Ethers
  • Stilbenes
  • Tubulin
  • fosbretabulin
  • Colchicine