Abstract
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Antineoplastic Agents, Phytogenic / chemical synthesis
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cell Cycle / drug effects
-
Cell Division / drug effects
-
Colchicine / antagonists & inhibitors
-
Colchicine / metabolism
-
Ethers / chemical synthesis
-
Ethers / chemistry
-
Ethers / pharmacology*
-
Humans
-
Inhibitory Concentration 50
-
Molecular Structure
-
Plants, Medicinal / chemistry
-
Protein Binding / drug effects
-
Stilbenes / chemical synthesis
-
Stilbenes / chemistry
-
Stilbenes / pharmacology*
-
Tubulin / metabolism
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Antineoplastic Agents, Phytogenic
-
Ethers
-
Stilbenes
-
Tubulin
-
fosbretabulin
-
Colchicine