TOR, a central controller of cell growth

T Schmelzle; M N Hall

doi:10.1016/s0092-8674(00)00117-3

TOR, a central controller of cell growth

Cell. 2000 Oct 13;103(2):253-62. doi: 10.1016/s0092-8674(00)00117-3.

Authors

T Schmelzle¹, M N Hall

Affiliation

¹ Department of Biochemistry, Biozentrum, University of Basel, Switzerland.

PMID: 11057898
DOI: 10.1016/s0092-8674(00)00117-3

Abstract

Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. Cyclin-dependent kinase(s) is the central regulator of cell proliferation. Is there an equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for cell growth, suggesting that this conserved kinase is such a central regulator.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Cycle Proteins
Cell Division*
Fungal Proteins / metabolism
Models, Biological
Phosphatidylinositol 3-Kinases*
Phosphotransferases (Alcohol Group Acceptor) / metabolism*
Protein Kinases*
Saccharomyces cerevisiae Proteins*
Signal Transduction*
TOR Serine-Threonine Kinases

Substances

Cell Cycle Proteins
Fungal Proteins
Saccharomyces cerevisiae Proteins
Protein Kinases
Phosphotransferases (Alcohol Group Acceptor)
TOR1 protein, S cerevisiae
TOR Serine-Threonine Kinases