Abstract
A network of cytokines and other soluble mediators unites the immune system and bone; bacterial infections induce immune responses which may perturb this network. Periodontal diseases are Gram-negative infections resulting in bone loss in the jaw. Evidence is presented that immune responses to these infections produces net resorption of bone.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alveolar Bone Loss / immunology*
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Alveolar Bone Loss / microbiology
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Alveolar Bone Loss / pathology
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Bone Remodeling
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Cytokines / metabolism
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Gram-Negative Bacteria / immunology
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Gram-Negative Bacteria / metabolism
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Gram-Negative Bacterial Infections / complications
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Gram-Negative Bacterial Infections / immunology*
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Gram-Negative Bacterial Infections / pathology
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Humans