Abstract
Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release.
MeSH terms
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Acetates / pharmacology*
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Amines*
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Animals
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Calcium / metabolism*
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Calcium Channel Blockers / administration & dosage
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Calcium Channel Blockers / pharmacology*
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Cyclohexanecarboxylic Acids*
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Dose-Response Relationship, Drug
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Gabapentin
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Male
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Osmolar Concentration
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Potassium / administration & dosage
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Potassium / pharmacology
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Potassium / physiology*
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Rats
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Rats, Sprague-Dawley
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Synaptosomes / metabolism*
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gamma-Aminobutyric Acid*
Substances
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Acetates
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Amines
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Calcium Channel Blockers
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Cyclohexanecarboxylic Acids
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gamma-Aminobutyric Acid
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Gabapentin
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Potassium
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Calcium