Membrane rafts and signaling by the multichain immune recognition receptors

C Langlet; A M Bernard; P Drevot; H T He

doi:10.1016/s0952-7915(00)00084-4

Membrane rafts and signaling by the multichain immune recognition receptors

Curr Opin Immunol. 2000 Jun;12(3):250-5. doi: 10.1016/s0952-7915(00)00084-4.

Authors

C Langlet¹, A M Bernard, P Drevot, H T He

Affiliation

¹ Centre d'Immunologie, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique (INSERM-CNRS) de Marseille-Luminy, Marseille, 13288, France.

PMID: 10781401
DOI: 10.1016/s0952-7915(00)00084-4

Abstract

The recent recognition of the presence of rafts in the plasma membrane and of their involvement in cell signaling has strongly stimulated the search for their function in receptor-mediated signal transduction in lymphocytes. Recent progress suggests that a general feature of membrane rafts is to serve as platforms wherein the signaling cascades triggered through different multichain immune recognition receptors (e.g. the TCR, BCR and FcepsilonRI) are initiated and organized.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Membrane / chemistry
Cell Membrane / metabolism*
Cell Membrane / ultrastructure*
Protein Structure, Tertiary
Receptors, Antigen, B-Cell / metabolism
Receptors, Antigen, T-Cell / metabolism
Receptors, IgE / metabolism
Receptors, Immunologic / chemistry
Receptors, Immunologic / metabolism*
Signal Transduction

Substances

Receptors, Antigen, B-Cell
Receptors, Antigen, T-Cell
Receptors, IgE
Receptors, Immunologic