Abstract
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
MeSH terms
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Animals
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Crystallography, X-Ray
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Cytoskeleton / ultrastructure
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Dyneins / chemistry
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GTP Phosphohydrolases / chemistry
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Humans
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Kinesins / chemistry
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Microtubules / chemistry*
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Models, Molecular
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Molecular Motor Proteins / chemistry
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Protein Conformation
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Protein Structure, Tertiary
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Tubulin / chemistry*
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Tubulin / metabolism
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tau Proteins / chemistry
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tau Proteins / metabolism
Substances
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Molecular Motor Proteins
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Tubulin
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tau Proteins
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GTP Phosphohydrolases
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Dyneins
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Kinesins