LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

R Schreiber; D Lowe; A Voerste; J De Vry

doi:10.1016/s0014-2999(99)00844-4

LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

Eur J Pharmacol. 2000 Jan 28;388(2):R3-4. doi: 10.1016/s0014-2999(99)00844-4.

Authors

R Schreiber¹, D Lowe, A Voerste, J De Vry

Affiliation

¹ CNS Research, Bayer, Aprather Weg 18, D-42096, Wuppertal, Germany. rudy.schreiber.rs1@bayer-ag.de

PMID: 10666513
DOI: 10.1016/s0014-2999(99)00844-4

Abstract

LY354740 ¿(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2, 6-dicarboxylate monohydrate¿, a selective group II metabotropic glutamate (mGlu) receptor agonist, was recently reported to attenuate the behavioral effects of phencyclidine (PCP) in rats. In the present study, LY354740 failed to attenuate the discriminative stimulus properties of PCP and its disruption of prepulse inhibition of the acoustic startle response, at a dose range which decreased startle responding. The suggestion that mGlu group II receptor activation induces antipsychotic effects may be premature.

MeSH terms

Acoustic Stimulation
Animals
Anti-Anxiety Agents / pharmacology*
Bridged Bicyclo Compounds / pharmacology*
Cues
Discrimination, Psychological / drug effects*
Dose-Response Relationship, Drug
Excitatory Amino Acid Agonists / pharmacology*
Excitatory Amino Acid Antagonists / pharmacology*
Male
Phencyclidine / pharmacology*
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, Metabotropic Glutamate / agonists*
Reflex, Startle / drug effects*

Substances

Anti-Anxiety Agents
Bridged Bicyclo Compounds
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
Receptors, Metabotropic Glutamate
Phencyclidine
eglumetad