Abstract
Intracellular signals are received and generated by the alpha(IIb)beta(3) integrin on platelets. Recent advances have been made in the areas of agonist receptors that initiate platelet activation, downstream signaling molecules (e.g. small G-proteins and kinases) and changes in ligand-occupied alpha(IIb)beta(3) that cause further signaling and clot retraction.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Adhesion Molecules / physiology
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Clot Retraction
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Enzyme Precursors / physiology
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Feedback
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Fibrinogen / physiology
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Focal Adhesion Kinase 1
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Focal Adhesion Protein-Tyrosine Kinases
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Humans
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Intracellular Signaling Peptides and Proteins
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Mice
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Mice, Knockout
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Phosphorylation
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Platelet Adhesiveness / drug effects
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Platelet Adhesiveness / physiology*
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Platelet Aggregation / drug effects
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Platelet Aggregation / physiology*
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Platelet Aggregation Inhibitors / pharmacology
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Platelet Glycoprotein GPIIb-IIIa Complex / chemistry
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Platelet Glycoprotein GPIIb-IIIa Complex / physiology*
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Protein Binding
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Protein Processing, Post-Translational
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Protein-Tyrosine Kinases / physiology
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Receptors, Cell Surface / agonists
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Receptors, Cell Surface / antagonists & inhibitors
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Signal Transduction / drug effects
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Signal Transduction / physiology*
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Syk Kinase
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Thrombospondins / physiology
Substances
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Cell Adhesion Molecules
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Enzyme Precursors
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Intracellular Signaling Peptides and Proteins
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Platelet Aggregation Inhibitors
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Platelet Glycoprotein GPIIb-IIIa Complex
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Receptors, Cell Surface
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Thrombospondins
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Fibrinogen
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Protein-Tyrosine Kinases
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Focal Adhesion Kinase 1
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Focal Adhesion Protein-Tyrosine Kinases
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PTK2 protein, human
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Ptk2 protein, mouse
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SYK protein, human
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Syk Kinase
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Syk protein, mouse