Abstract
The nitric oxide (NO) synthase family of enzymes generate NO from L-arginine, which acts as a biologic effector molecule in a broad number of settings. This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Arginine / metabolism
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Boranes / chemistry
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Calmodulin / chemistry
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Catalysis
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Cattle
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Mammals / metabolism*
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Mice
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase / chemistry*
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Nitric Oxide Synthase / metabolism*
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Nitric Oxide Synthase Type I
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Nitric Oxide Synthase Type II
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Nitric Oxide Synthase Type III
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Rats
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Signal Transduction
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Structure-Activity Relationship
Substances
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Boranes
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Calmodulin
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Nitric Oxide
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Arginine
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type I
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Nitric Oxide Synthase Type II
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Nitric Oxide Synthase Type III
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Nos1 protein, mouse
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Nos1 protein, rat
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Nos2 protein, mouse
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Nos2 protein, rat
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Nos3 protein, mouse
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Nos3 protein, rat