Abstract
Antimorphine antibodies produced in Rhesus monkeys immunized with morphine-6-hemisuccinate-BSA were passively administered to recipient monkeys trained to self-administer heroin and cocaine. Following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. Both manipulations increased heroin self-administration without affecting cocaine responding.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cocaine / administration & dosage
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Conditioning, Operant / drug effects
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Haplorhini
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Heroin / administration & dosage
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Heroin Dependence / immunology*
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Humans
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Immune Sera / pharmacology*
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Immunity, Maternally-Acquired*
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Macaca mulatta
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Morphine / immunology*
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Naloxone / pharmacology
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Self Administration
Substances
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Immune Sera
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Naloxone
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Heroin
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Morphine
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Cocaine