Abstract
There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetyltransferases / genetics*
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Acetyltransferases / physiology
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Animals
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Cell Division
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Neoplastic
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Histone Acetyltransferases
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Histone Deacetylases / genetics*
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Histone Deacetylases / physiology
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Humans
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Neoplasms / enzymology
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Neoplasms / genetics
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Saccharomyces cerevisiae Proteins*
Substances
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Saccharomyces cerevisiae Proteins
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Acetyltransferases
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Histone Acetyltransferases
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Histone Deacetylases