Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Effect of Grapefruit Juice on the Urinary 6β-hydroxycortisol/cortisol Ratio
HIROYOSHI NAKAMURASHINICHI YAMAGATAMIYUKI SAWAIHITOSHI NAKAMURASHIGERU OHMORIMITSUKAZU KITADA
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1997 Volume 23 Issue 2 Pages 134-139

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Abstract

The effect of grapefruit juice on the urinary 6β-hydroxycortisolicortisol ratio was investigated in healthy volunteers. The urinary concentration of cortisol was virtually unaffected by the administration of grapefruit juice whereas the concetration of 6β-hydroxycortisol in the urine decreased when grapefruit juice was given every 3 hours. The administration of grapefruit juice was thus considered to result in a decrease in the urinary 6β-hydroxycortisol/cortisol ratio. In addition, both diurnal and individual differences were also observed in the extent of the inhibitory effect of grapefruit juice.

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