Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages

Kazuyoshi Manabe; Yasuhiko Nishioka; Jun Kishi; Mami Inayama; Yoshinori Aono; Yoichi Nakamura; Fumitaka Ogushi; Hiroyasu Bando; Kenji Tani; Saburo Sone

doi:10.2152/jmi.52.85

Originals

Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages

Kazuyoshi Manabe, Yasuhiko Nishioka, Jun Kishi, Mami Inayama, Yoshinori Aono, Yoichi Nakamura, Fumitaka Ogushi, Hiroyasu Bando, Kenji Tani, Saburo Sone

Author information

Kazuyoshi Manabe
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Yasuhiko Nishioka
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Jun Kishi
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Mami Inayama
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Yoshinori Aono
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Yoichi Nakamura
Clinical Research Center for Allergy and Rheumatology, National Kochi Hospital
Fumitaka Ogushi
Clinical Research Center for Allergy and Rheumatology, National Kochi Hospital
Hiroyasu Bando
Department of Pulmonary Medicine, Tokushima Prefectural Central Hospital
Kenji Tani
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
Saburo Sone
Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School

Keywords: bronchoalveolar lavage fluid, macrophage-derived chemokine, thymus-and activation-regulated chemokine, eosinophilic pneumonia, alveolar macrophages, interstitial lung diseases

JOURNAL FREE ACCESS

2005 Volume 52 Issue 1,2 Pages 85-92

DOI https://doi.org/10.2152/jmi.52.85

Details

Abstract

Macrophage-derived chemokine (MDC/CCL22) and thymus-and activation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP. J. Med. Invest. 52: 85-92, February, 2005

Corresponding author

Register with J-STAGE for free!