Chest
Experimental ApproachesThe Role of Leukocytes in Ethchlorvynol-Induced Pulmonary Edema
Section snippets
In Vivo
Normal Dogs. Normal dogs were those not treated with cyclophosphamide (Cytoxan). Seven mongrel dogs were anesthetized with an intravenous injection of 30 mg of pentobarbital sodium per kilogram of body weight. The dogs were intubated and ventilated with a respirator (Harvard) at a fractional concentration of oxygen in the inspired gas (FIo2) of 1.0, and the following catheters were inserted: (1) a No. 7 Swan-Ganz catheter via the femoral vein into the pulmonary artery under pressure monitoring;
In Vivo Studies
Normal Dogs (Not Treated with Cyclophosphamide). Table 1 gives the total leukocyte counts of pulmonary arterial and arterial blood before and one, three, and five minutes after injection of ethchlorvynol. Prior to the injection of ethchlorvynol, the arterial leukocyte counts tended to be lower than those found in the pulmonary artery. Following injection of ethchlorvynol, the differences between pulmonary arterial blood and arterial blood increased markedly in all animals at all times of
Discussion
We became interested in the pulmonary edematogenic properties of ethchlorvynol after caring for two young patients who initially had respiratory insufficiency (adult respiratory distress syndrome) after the intravenous injection of this common oral sedative.9 Ongoing studies have revealed the following: intravenously administered ethchlorvynol accumulates in a passive fashion in pulmonary tissue within minutes of injection;10 the permeability of alveolar capillary membranes is markedly
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Ethchlorvynol-induced pulmonary edema: A chronically instrumented, awake sheep model mimicking human disease
1987, American Journal of the Medical SciencesPulmonary edema induced by intravenous ethchlorvynol
1986, American Journal of Emergency MedicineMediators of septic lung injury
1983, Medical Clinics of North AmericaThe adult respiratory distress syndrome
1981, Disease-a-Month