Chest
Laboratory and Animal InvestigationsElevated Levels of Soluble Adhesion Molecules in Serum of Patients With Diffuse Panbronchiolitis
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Study Population
The study population consisted of two groups of patients with chronic neutrophil-mediated airway inflammation, including 27 patients with DPB (13 female and 14 male), 13 patients with bronchiectasis (9 female and 4 male), and healthy volunteers (control subjects, n=15: 8 female and 7 male). Healthy volunteers (aged 31 ±11 years) were younger than patients with DPB (48±16 years) and bronchiectasis (60±14 years). At the time of the investigation, one patient with bronchiectasis and one volunteer
Serum Levels of Soluble Selectins
The serum levels of sL-selectin in patients with DPB and bronchiectasis were significantly higher than in volunteer subjects (Fig 1A [top]). The serum levels of sE-selectin in patients with DPB were significantly higher than those in patients with bronchiectasis and volunteers (Fig 1B [center]). The mean serum level of sP-selectin in patients with DPB was significantly higher than in healthy volunteers and patients with bronchiectasis (Fig 1C [bottom]).
Serum Levels of Soluble ICAM-1 and VCAM-1
The serum levels of sICAM-1 and sVCAM-1 in
Discussion
The present study demonstrated the presence of elevated serum levels of soluble adhesion molecules in patients with chronic neutrophil-mediated airway inflammation, particularly DPB. These results, together with those from other studies, suggest that accumulation of neutrophils in the airway of DPB patients results from infiltration of these cells from the circulation following a series of processes involving several adhesion molecules present on the surface of these cells and cytokine-induced
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2001, ChestCitation Excerpt :Type I diabetics but not type II diabetics also showed correlation with disease activity.20 Other studies2122 have investigated atopic dermatitis and diffuse panbronchiolitis and found elevated sL-selectin serum activity associated with increased disease activity. CNS disease has been extensively investigated to correlate disease activity with sL-selectin levels in the CSF.