Effect of Antibodies Against Intercellular Adhesion Molecule-1, B7, and CD40 on Interleukin-18-Treated Human Mixed Lymphocyte Reaction

Hideo Kohka Takahashi; Hiromi Iwagaki; Ryuji Tamura; Takahito Yagi; Tadashi Yoshino; Shuji Mori; Noriaki Tanaka; Masahiro Nishibori

doi:10.1254/jphs.SC0040167

Short Communications

Effect of Antibodies Against Intercellular Adhesion Molecule-1, B7, and CD40 on Interleukin-18-Treated Human Mixed Lymphocyte Reaction

Hideo Kohka Takahashi, Hiromi Iwagaki, Ryuji Tamura, Takahito Yagi, Tadashi Yoshino, Shuji Mori, Noriaki Tanaka, Masahiro Nishibori

Author information

Hideo Kohka Takahashi
Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
Hiromi Iwagaki
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
Ryuji Tamura
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
Takahito Yagi
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
Tadashi Yoshino
Department of Pathology, Okayama University Graduate School of Medicine and Dentistry
Shuji Mori
Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry
Noriaki Tanaka
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
Masahiro Nishibori
Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry

Keywords: interleukin-18, mixed lymphocyte reaction, adhesion molecule

JOURNAL FREE ACCESS

2005 Volume 97 Issue 3 Pages 447-450

DOI https://doi.org/10.1254/jphs.SC0040167

View "Advance Publication" version (March 12, 2005).

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Abstract

The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.

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