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k Opioids as potential treatments for stimulant dependence

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Abstract

Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the “dopamine hypothesis” has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor in mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of κ opioid agonists. The κ receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes of κ opioid ligands that have been explored for this purpose.

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Authors and Affiliations

  1. Division of Medicinal & Natural Products Chemistry, College of Pharmacy, The University of Iowa, 52242, Iowa City, Iowa

    Thomas E. Prisinzano, Kevin Tidgewell & Wayne W. Harding

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  1. Thomas E. Prisinzano
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  2. Kevin Tidgewell
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  3. Wayne W. Harding
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Correspondence to Thomas E. Prisinzano.

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Published: October 19, 2005

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Prisinzano, T.E., Tidgewell, K. & Harding, W.W. k Opioids as potential treatments for stimulant dependence. AAPS J 7, 61 (2005). https://doi.org/10.1208/aapsj070361

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